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KMID : 0617320010100010049
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Journal of Pharmacetical Sceiences Ewha Womans University
2001 Volume.10 No. 1 p.49 ~ p.51
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Macharistol, a New Cytotoxic Cinnamylphenol from the Stems of Machaerium aristulatum
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Seo, Eun-Kyoung
Kim, Nam-Cheol/Mi, Qiuwen/Chai, Heebyung/Wall, Monroe E./Wani, Mansukh C./Navarro, Herna´n A.
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Abstract
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A new clnnamylphenol, machaistol(1), along with a known pterocarpan, (+)-medicarpin(2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain(3), and a known isoflavone, formononetin(4), were identified as inactive constituents. Compound 1 was eveluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest does(25 mg/kg body weight) tested.
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